Sweet 16 point spreads, odds for each men’s NCAA tournament regional semifinal game

Alabama forward Brandon Miller, left, reacts after a 3-pointer during the second half of the team's second-round college basketball game against Maryland in the men's NCAA Tournament in Birmingham, Ala., Saturday, March 18, 2023. (AP Photo/Butch Dill)

With the first two rounds of the men’s basketball NCAA tournament complete, we’re down to the Sweet 16 for another year. Now, with a few days off before the next round, it’s time to look at some point spreads, money-line odds and over/unders for the regional semifinals.

It’s no surprise that the remaining No. 1 seeds, Alabama and Houston, are not only the national title favorites but also heavy chalk in their next matchup. The Crimson Tide is a 7½-point favorite over No. 5 seed San Diego State in the South Region at FanDuel Sportsbook, while the Cougars are -7.5 against No. 5 Miami in the Midwest.

But the biggest favorite in the Sweet 16 is actually South No. 6 seed Creighton, which drew No. 15 seed Princeton and is favored by 9.5. But beware: Last season, No. 15 seed St. Peter’s beat No. 3 Purdue outright as a 13-point underdog.

Only one lower seed is favored. That’s Michigan State, which is 1.5-point chalk as the East No. 7 seed over No. 3 Kansas State.

Here is a complete list of lines and over/unders from FanDuel Sportsbook:

Sweet 16 odds

(As of Tuesday morning; view updated lines here)


East Region: No. 7 Michigan State (-1.5, ML -134) vs. No. 3 Kansas State (ML +112, o/u 137.5), 6:30 p.m.

West Region: No. 4 UConn (-3.5, ML -178) vs. No. 8 Arkansas (ML +146, o/u 139.5), 7:15 p.m.

East Region: No. 4 Tennessee (-4.5, ML -245) vs. No. 9 Florida Atlantic (ML +198, o/u 130.5), 9 p.m.

West Region: No. 2 UCLA (-2.5, ML -130) vs. No. 3 Gonzaga (ML +108, o/u 145.5), 9:45 p.m.


South Region: No. 1 Alabama (-7.5, ML -345) vs. No. 5 San Diego State (ML +270, o/u 137.5), 6:30 p.m.

Midwest Region: No. 1 Houston (-7.5, ML -320) vs. No. 5 Miami (ML +250, o/u 137.5), 7:15 p.m.

South Region: No. 6 Creighton (-9.5, ML -580) vs. No. 15 Princeton (ML +420, o/u 139.5), 9 p.m.

Midwest Region: No. 2 Texas (-3.5, ML -184) vs. No. 3 Xavier (ML +152, o/u 148.5), 9:45 p.m.


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